The incorporation of strontium to improve bone-regeneration ability of mesoporous bioactive glasses
Authors: Sonia Fiorilli, Giulia Molino, Carlotta Pontremoli, Giorgio Iviglia, Elisa Torre, Clara Cassinelli, Marco Morra, Chiara Vitale-Brovarone * State-of-the-Art Materials Science in Italy 2017
The synergistic combination of the excellent bioactivity of mesoporous bioactive glasses (MBGs) and the pro-osteogenic potential of strontium ions represents a very promising approach for stimulating bone remodelling. The developed Sr-containing MBGs stimulated the precipitation of hydroxyapatite crystals, showed a reduced pro-inflammatory response and were able to stimulate the expression of pro-osteogenic genes. These results will pave the way for the design of advanced systems for the treatment of bone pathologies, particularly in patients with osteoporosis.